Science & Research
State of the art research and development and pre-clinical and clinical trials for ProLon® were conducted at the University of Southern California’s Longevity Institute and Diabetes and Obesity Research Institute , and sponsored by the National Cancer Institutes (NCI) and National Institute on Aging (NIA) of the National Institute of Health (NIH).
The results of the above research were published in top scientific peer-reviewed journals.
Nobel Prize in Autophagy
The Nobel Assembly at Karolinska Institutet awarded the 2016 Nobel Prize in Physiology or Medicine to Yoshinori Ohsumi for his discoveries of mechanisms for autophagy.
Ohsumi’s discoveries led to a new paradigm in our understanding of how the cell recycles its content. His discoveries opened the path to understanding the fundamental importance of autophagy in many physiological processes.
Autophagy has been known for over 50 years but its fundamental importance in physiology and medicine was only recognized after Yoshinori Ohsumi’s paradigm-shifting research in the 1990’s.
Thanks to Ohsumi and others following in his footsteps, we now know that autophagy controls important physiological functions where cellular components need to be degraded and recycled.
Autophagy can rapidly provide fuel for energy and building blocks for renewal of cellular components, and is therefore essential for the cellular response to starvation and other types of stress. After infection, autophagy can eliminate invading intracellular bacteria and viruses.
Autophagy contributes to embryo development and cell differentiation. Cells also use autophagy to eliminate damaged proteins and organelles, a quality control mechanism that is critical for counteracting the negative consequences of aging.