Science & Research
State of the art research and development and pre-clinical and clinical trials for ProLon® were conducted at the University of Southern California’s Longevity Institute and Diabetes and Obesity Research Institute , and sponsored by the National Cancer Institutes (NCI) and National Institute on Aging (NIA) of the National Institute of Health (NIH).
The results of the above research were published in top scientific peer-reviewed journals.
Nobel Prize in Autophagy
The Nobel Assembly at Karolinska Institutet awarded the 2016 Nobel Prize in Physiology or Medicine to Yoshinori Ohsumi for his discoveries of mechanisms for autophagy.
Ohsumi’s discoveries led to a new paradigm in our understanding of how the cell recycles its content. His discoveries opened the path to understanding the fundamental importance of autophagy in many physiological processes.
Fasting Mimicking Diet® Patents
Methods and formulations promoting tissue/organ rejuvenation, longevity and healthspan.
Patent Number: US10015980
Publication Date: July 10, 2018
Inventors: Valter D. Longo, Sebastian Brankhorst, Levine, Chia-Wei Cheng, Min Wei
$36
millions
in research funding
9,500
health practitioners
recommending our products
120,000
patients
using ProLon
Scientific Articles
Science Translational Medicine
February 2017
Fasting-mimicking diet and markers/risk factors for ageing, diabetes, cancer, and cardiovascular disease.
Cell Press
August 2016
Enhancing cell transplantation with “Nutri-technology”.
JAMA
August 2016
Association of Animal and Plant Protein Intake With All-Cause and Cause-Specific Mortality
Cell Press
July 2016
Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity.
Biomed Central
June 2016
Dietary Interventions, Cardiovascular Ageing, and Disease Animal Models and Human Studies
Circulation Research
May 2016
Dietary Interventions, Cardiovascular Ageing, and Disease Animal Models and Human Studies
Cell Press
May 2016
A Diet Mimicking Fasting Promotes Rejuvenation and Reduces Autoimmunity and Multiple Sclerosis Symptoms.
Cell Metabolism
July 7, 2015
A periodic diet that mimics fasting and promotes multi-system Rejuvenation, enhanced cognitive performance, and health span.
Aging Cell
March 11, 2013
Protein restriction cycles reduce IGF-1 and phosphorylated Tau, and improve behavioral performance in an Alzheimer’s disease mouse model.
Autophagy has been known for over 50 years but its fundamental importance in physiology and medicine was only recognized after Yoshinori Ohsumi’s paradigm-shifting research in the 1990’s.
Thanks to Ohsumi and others following in his footsteps, we now know that autophagy controls important physiological functions where cellular components need to be degraded and recycled.
Autophagy can rapidly provide fuel for energy and building blocks for renewal of cellular components, and is therefore essential for the cellular response to starvation and other types of stress. After infection, autophagy can eliminate invading intracellular bacteria and viruses.
Autophagy contributes to embryo development and cell differentiation. Cells also use autophagy to eliminate damaged proteins and organelles, a quality control mechanism that is critical for counteracting the negative consequences of aging.